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A hantavirus is a virus found in the urine, saliva or excrement of deer mice and certain other infected wild rodents (Icy Macload/Getty Images)

(LONDON and BELGRADE, Serbia) — The total number of suspected hantavirus cases aboard a cruise ship has risen to five as global health authorities work to contain a potentially deadly cluster of the disease.

More than 100 passengers remain on the ship and the World Health Organization (WHO) is monitoring their health. Officials said that the “overall public health risk remains low” but that there may be some person-to-person spread.

The ship, the MV Hondius, which was off the coast of Africa in Cape Verde, is now en route to the Canary Islands after officials medically evacuated three people, including two in “serious condition.”

Some passengers disembarked the ship before knowledge of the cluster and are back in their home countries. In some cases, authorities are advising those passengers to self-isolate.

In addition to the two patients who were evacuated, a third person, who is asymptomatic but a close contact of a German national who died on May 2, was also removed from the ship, WHO officials in Cape Verde told ABC News.

“WHO continues to work with the ship’s operators to closely monitor the health of passengers and crew, working with countries to support appropriate medical follow-up and evacuation where needed,” Dr. Tedros Adhanom Ghebreyesus, the director-general of the WHO, said in a post on X on Wednesday, in which he confirmed the evacuations.

“Monitoring and follow-up for passengers on board and for those who have already disembarked has been initiated in collaboration with the ship’s operators and national health authorities,” he continued.

Tedros added that “the overall public health risk remains low.”

Health officials confirmed two additional cases of hantavirus among crewmembers, bringing the total confirmed cases to five.

The three previously confirmed hantavirus cases include a woman who disembarked and was on her way home from the Netherlands, a British national who is in critical but stable condition in a hospital in Johannesburg, and a passenger who traveled on the first leg of the voyage and is currently being treated at the University Hospital Zurich, according to Oceanwide Expeditions, which operates the ship. So far, three deaths have been recorded.

“Swiss authorities have confirmed a case of hantavirus identified in a passenger from the MV Hondius cruise ship,” the WHO said on X on Wednesday. “He had responded to an email from the ship’s operator informing the passengers of the health event, and presented himself to a hospital in Zurich, Switzerland, and is receiving care.”

The type of virus in this outbreak has been confirmed as Andes hantavirus by the National Institute for Communicable Diseases in South Africa and Geneva University Hospitals in Switzerland, the WHO said Wednesday. The Andes hantavirus historically has been shown to potentially transmit between people, according to the WHO.

Oceanwide Expeditions said of the three passengers who were evacuated from the ship, two are symptomatic and in serious condition and the third is asymptomatic but a close contact of a German national who died on May 2.

“In partnership with the RIVM (Dutch Institute for Public Health and Environment), Oceanwide Expeditions is expanding medical care on board with two infectious disease physicians, arriving today by plane from the Netherlands. This ensures that optimal medical care can be provided if necessary, during the next stage of this evolving situation,” the company said in a statement.

Cape Verde officials said on Tuesday that the vessel was expected to sail to the Spanish island of Tenerife, but the president of the Canary Islands, a Spanish archipelago off the northwestern coast of Africa, said on Wednesday that the regional government was opposed to allowing the luxury cruise ship to dock in Tenerife. 

“This decision is not based on any technical criteria, nor is there sufficient information to reassure the public or guarantee their safety,” President Fernando Clavijo told radio station COPE, according to Reuters.

Clavijo said on social media that he had requested a meeting with the Spanish prime minister to discuss the ship. He added that the Canary Islands “always acts with responsibility, but it cannot accept decisions taken behind the backs of the Canary Islands institutions and without sufficient information to the population.”

Mónica García, Spain’s minister of health, said once the ship arrives at the port of Granadilla de Abona in the Canary Islands, there will be a “joint screening and evacuation mechanism will be launched to repatriate all passengers,” according to RTVE, a Spanish national public broadcaster.

“Unless their medical condition prevents it, all foreign passengers will be repatriated through the European civil protection mechanism, about which the Interior Minister will provide further details later,” Garcia said in Spanish.

WHO officials earlier on Wednesday said the three evacuated people were to be transferred to planes bound for both the Netherlands and Tenerife, but later updated the plan so that all would be sent to the Netherlands, officials told ABC News.

ABC News’ Othon Leyva contributed to this report.

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